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Cannabinoids are the naturally occurring chemical compounds found in the cannabis plant. Cannabinoids are partly responsible for the wide array of medicinal and psychoactive effects cannabis may provide. Currently there are over 110 known cannabinoids with more likely to be discovered as studies continue to reveal the complex molecular structures of the cannabis plant.
Cannabinoids interact with human physiology through the endocannabinoid system (ECS), the set of receptors that function to regulate health and promote homeostasis throughout the body. The ECS has two primary receptors, the CB1 and CB2. The CB1 receptor binds primarily to the brain and nervous system, while the CB2 receptor interacts largely with the immune system. The cannabis plant relies on cannabinoids binding to these receptors to produce the array of potential benefits and effects. Each cannabinoid holds unique characteristics of their own that are worth noting in order to maximize desired effects from medicating with cannabis.
Cannabigerol (CBG) is a non-psychoactive cannabinoid that plays an important role in the biochemistry of the cannabis plant. CBG acts as a chemical precursor to other cannabinoids such as THC and CBD. This conversion typically takes place 6-8 weeks in the flowering cycle. CBG is present only in trace amounts in most cannabis strains, however some hemp strains are specifically cultivated to generate higher yields of this cannabinoid.
CBG displays a multitude of potential health benefits including working as a neuroprotectant, having antioxidant properties, aiding with skin ailments as an antibacterial and antifungal agent, appetite stimulation, treatment of gastrointestinal disorders, inflammation reduction, shows promise in fighting cancer, and lowering intraocular pressure, which may benefit glaucoma patients.
CBG interacts with both the CB1 and CB2 receptors, acting as a possible inhibitor to the psychoactive effects of THC. CBG is also thought to boost anandamide, an endocannabinoid that naturally increases dopamine levels and responsible for regulating various health functions such as mood, sleep, and appetite. GABA uptake in the brain may be obstructed by CBG, making this cannabinoid a possible anti-anxiety agent and muscle relaxant. CBG may also block serotonin receptors, showing potential antidepressant traits.
CBG holds promise to be a key constituent in the overall medicinal benefits cannabis may provide. As cannabis research continues to rapidly evolve, CBG may emerge as one of the most therapeutically applicable and diverse cannabinoids to offer a wide range of possible remedies. Feel free to ask any of our knowledgeable patient consultants with any questions you may have.
CBG was examined for lowering intraocular pressure in a 1990 study, making it a possible glaucoma treatment. In a 2008 study CBG was found to be possibly beneficial in the treatment of MRSA due to its antibacterial and antifungal properties. A December 2014 study explored CBG as a possible agent to combat colorectal cancer. The neuroprotective properties of CBG were the subject of a January 2015 study, suggesting therapeutic potential for Huntington’s disease. CBG showed to be a particularly effective cannabinoid in a June 2015 study that focused on bladder dysfunction treatment options. An October 2016 study showed CBG to be potentially effective for inducing appetite.
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